Projets de recherche

Projets de recherche

Characterizing the antimicrobial susceptibility of A. fumigatus and S. maltophilia alone and in association

1. Describing the epidemiology of azole resistance in Aspergillus fumigatus and exploring new therapeutic options

The emergence of azole resistance in A. fumigatus is a growing problem in Europe as well in other continents, and there is currently an international incentive to obtain reliable epidemiological data in as many countries as possible. Evaluation of new detection methods of resistance is also a recommended milestone.

Evaluate the prevalence of azole-resistance both in patients and in the environment in Tunisia, in Guyane Française and in Martinique.

2. Describing the epidemiology of drug resistance in Stenotrophomonas maltophilia

S. matophilia is a naturally multidrug resistant bacterium owing to the presence of numerous efflux pumps and betalactamases. Additional acquired resistant genes could lead to pan resistant phenotype.

Explore the genetic background from two human and animal collections of strains and molecular support of resistant traits. We aim to assess the prevalence of resistance rate according to the antimicrobial pressure.

3. Characterizing antimicrobial drug resistance when A. fumigatus and S. maltophilia are associated in a biofilm

We aim to assess the impact of the coculturing of these two pathogens on their respective antimicrobial susceptibilities.

Analyze the effect of different antimicrobial agents against this fungal-bacterial biofilm compared to mono-species biofilms.